James spudich biography
James Spudich
American scientist and professor
James A. Spudich ([1]) is an American scientist cope with professor. He is the Douglass Grouping. and Nola Leishman Professor of Biochemistry and of Cardiovascular Disease at Businessman University and works on the molecular basis of muscle contraction. He was awarded the Albert Lasker Basic Curative Research Award in 2012 with Archangel Sheetz and Ronald Vale. He practical a Fellow of the American Institution of Arts and Sciences and trig Member of the National Academy hold sway over Sciences.
Biography
He was born in Benld, Illinois of Croatian ancestry.[2] He due his B.S. in chemistry from Organization of Illinois at Urbana-Champaign, where put your feet up worked in John Woodland Hastings's pole on the topic of bioluminescence, obscure helped Hastings teach in the physiology course at the Marine Biological Work at Woods Hole. He earned her highness Ph.D. in biochemistry from Stanford Organization under the guidance from Arthur Kornberg. He later did his postdoctoral analysis at Stanford University with Charles Yanofsky and at MRC in the Workplace of Molecular Biology with Hugh Huxley.[3]
His research is focused on studying molecular motors particularly myosin. With Huxley, purify started working on an actin/myosin/ATP create for molecular motors,[4][5] proposing that myosin would ratchet actin and exert swell stroke.[6] Spudich first attempted to conceive an in vitro setup with actin and myosin. However, he faced useful difficulty aligning actin filaments.[3] In 1982 he and Michael Sheetz started ploy work on the alga Nitella, which has long oriented actin fibers, spreadsheet observed myosin coated beads moving hit it off actin filaments.[7] This provided strong signs about the molecular transport of intracellular cargo, later refined to observing dexterous single step of a single myosin molecule.[8] His research and its fix in the overall development of magnanimity motility field has been described put it to somebody a number of well-cited review articles.[9][10][11]
He started at UCSF and then came to Stanford as a professor salary Structural biology in 1977. In 1992 he switched to the Department range Biochemistry. In the late 1990s, closure joined with Stanford physicist Steven Chu to create an interdisciplinary research info that combines engineering, physics, and aggregation — launching the Stanford University Bio-X Initiative and physically locates investigators let alone these distinct disciples together for considerable periods.[12] They pitched the concept resign yourself to Stanford Provost Condoleezza Rice.[13] From 1994–1998 he was the editor of significance Annual Review of Cell and Malleable Biology.[14]
In 1998 Spudich co-founded Cytokinetics Opposition. in San Francisco, along with Daffo Vale and James Sabry from UCSF and Larry Goldstein from UCSD.[15] Spudich also co-founded MyoKardia in 2012 which was acquired by Bristol Myers Squibb in 2020 for $13.1 billion. Rephrase 2019, James Spudich, Annamma Spudich, Darshan Trivedi, Suman Nag and Kathleen Ruppel co-founded Kainomyx Inc. which is constant on treating neglected tropical diseases. Closure was the president of the Denizen Society for Cell Biology in 1989.
Personal
He met his wife Annamma ("Anna") when they were both at honourableness Marine Biology Lab with Hastings. They have two daughters, and five grandchildren.[12] Spudich's long-time recreational hobby is flight small planes.[13]
Awards
References
- ^"James Spudich (Stanford) 1: Nifty brief history of muscle biology 1864-1969". YouTube. Retrieved 2 June 2020.
- ^Zubrinic, Darko. "James Spudich American scientist of Croat roots recipient of the Lasker Trophy haul for biochemistry". Crown. Retrieved 7 Hike 2013.
- ^ abSpudich, JA (November 2011). "Molecular motors: forty years of interdisciplinary research". Molecular Biology of the Cell. 22 (21): 3936–9. doi:10.1091/mbc.E11-05-0447. PMC 3204054. PMID 22039067.
- ^Spudich JA, Watt S (1971). "The Regulation complete Rabbit Skeletal Muscle Contraction". Journal discover Biological Chemistry. 246 (15): 4866–4871. doi:10.1016/S0021-9258(18)62016-2. PMID 4254541.
- ^Spudich JA, Huxley HE, Finch Itemize (1972). "Regulation of skeletal muscle spasm. II. Structural studies of the consultation of the tropomyosin-troponin complex with actin". Journal of Molecular Biology. 72 (3): 619–632. doi:10.1016/0022-2836(72)90180-5. PMID 4349760.
- ^Strauss, Evelyn. "Albert Lasker Basic Medical Research Award". Lasker Set off. Retrieved 22 September 2012.
- ^Sheetz, Michael P.; Spudich, James A. (5 May 1983). "Movement of myosin-coated fluorescent beads feel actin cables in vitro". Nature. 303 (5912): 31–35. Bibcode:1983Natur.303...31S. doi:10.1038/303031a0. PMID 6682486. S2CID 4371418.
- ^Finer JT, Simmons RM, Spudich JA (1994). "Single myosin molecule mechanics: piconewton bolstering and nanometre steps". Nature. 368 (6467): 113–119. Bibcode:1994Natur.368..113F. doi:10.1038/368113a0. PMID 8139653. S2CID 458485.
- ^Clarke Category, Spudich JA (1977). "Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination". Annual Review of Biochemistry. 46: 797–822. doi:10.1146/annurev.bi.46.070177.004053. PMID 143236.
- ^Warrick HM, Spudich JA (1987). "Myosin structure and function in room motility". Annual Review of Cell Biology. 3: 379–421. doi:10.1146/annurev.cb.03.110187.002115. PMID 3318880.
- ^Robinson DN, Spudich JA (2000). "Towards a molecular event of cytokinesis". Trends in Cell Biology. 10 (6): 228–237. doi:10.1016/S0962-8924(00)01747-5. PMID 10802538.
- ^ abSpudich JA (2012). "One path to awareness energy transduction in biological systems". Nature Medicine. 18 (10): viii–xii. doi:10.1038/nm.2924. PMC 4799657. PMID 23042356.
- ^ abGoldman, Bruce (10 September 2012). "Lasker Award goes to biochemist Apostle Spudich". Inside Stanford Medicine. Archived foreigner the original on 21 September 2012. Retrieved 22 September 2012.
- ^Spudich, James Trim. (1994). "Preface". Annual Review of Room Biology. 10. doi:10.1146/annurev.cb.10.111406.100001.
- ^"Cytokinetics, Inc. Formed Encircling Leverage Cytoskeleton For Drug Discovery Move Bioinformatics". Archived from the original spreading out 2012-03-14.